Apr 23, - Ok, let's get the scary stuff outta' the way right up front so you can pay . Reduction in alcohol can reduce estrogen-related breast pain and your. Aug 4, - Treatment. Eliminate an underlying cause or aggravating factor. This may involve a simple adjustment, such as wearing a bra with extra support. Use a topical nonsteroidal anti-inflammatory (NSAID) medication. Adjust birth control pills. Reduce the dose of menopausal hormone therapy. Take a prescription medication.